Latest
13
Apr
First Principles: How to Think Like a Greek and Build Like a Founder
There’s an old saying in Silicon Valley: when in doubt, invoke physics. And so the term “first principles” has
3 min read
12
Apr
Get Messy: Why Diving In Beats Waiting for Perfection
There’s a curious delusion that haunts modern professionals. The belief that before you start something—anything, really—you must
2 min read
11
Apr
P-Hacking: The Fine Art of Massaging Numbers into Compliance
What Is a p-Value?
The p-value measures the probability of observing data as extreme as the actual results, assuming the
4 min read
10
Apr
The Runway Is Shorter Than It Looks
There’s a specific look founders get when I ask, “What’s your runway?” It’s part shame, part bravado,
2 min read
09
Apr
The Cocktail Party Problem: How to Survive Conferences, Science, and Other Noisy Mistakes
There you are—armed with a lukewarm flute of prosecco, trying to make small talk with a stem cell biologist
3 min read
08
Apr
Let’s Do It: A Short Manifesto for the Overcommitted
There’s a peculiar optimism embedded in the English language: pulling yourself up by your bootstraps. The phrase is now
2 min read
07
Apr
In Praise of Productive Delusion
In Germany, there is a saying: "Wenn du Visionen hast, geh zum Arzt.” If you have visions, see a
3 min read
06
Apr
Simping for Capital: The Cult of the Curated Investor List
In the courtship rituals of modern fundraising, there exists a peculiar form of digital simping: the obsessive fawning over “curated
2 min read
05
Apr
The Unaccountability Machine: When Systems Go Mad (and No One Gets Fired)
Dan Davies—veteran analyst, ex-regulator, and professional myth-buster—has written what might be the most depressingly accurate book of 2024:
3 min read
04
Apr
Super-Responders and Extreme Value Theory (EVT): Unlocking Opportunities in Pharma and Biotech
In drug development, most narratives hinge on averages—median survival times, mean biomarker expression, or standard response rates. Yet, breakthroughs
4 min read