The Weekly Term Sheet (52)
The final full week of 2025 delivered over $10.5 billion in biotech and pharma transactions despite the holiday lull.
When Pharmaceutical Promises May Become Tradable Assets: CVRs, Royalties, and the Market for Contingent Drug Payments
The pharmaceutical industry runs on promises. Drug companies promise to pay royalties when products succeed. Acquirers promise additional payments if
The Great Biotech Cash Arbitrage: Anatomy of a Sector in Distress
A record 161 biotechnology companies traded at negative enterprise value in mid-2025, representing over $5 billion in trapped capital where shareholders hold claims on cash that market prices say is worth less than nothing.
The Twelve Deals of Christmas
Biotech's 2025 was a year of contradictions. Venture funding collapsed to 2012 levels while the XBI climbed 37%. Startup formation cratered 70% while Big Pharma wrote $20+ billion in M&A checks.
Biotech's Holiday Wishlist for 2026
Tongue-in-cheek wishes for the biotech industry – from faster trials to friendlier FDA letters – that would make the new year a little brighter for all.
Decoupling Dilemmas: China Biotech's Global Balancing Act
East meets West in the lab and the marketplace – how China's evolving biotech sector is navigating US tensions, domestic pressures, and forging a new path forward into 2026.
Zymeworks' Royalty-Driven Pivot: From Canadian Biotech Aspirant to Hybrid Royalty Aggregator
Zymeworks Inc. (NASDAQ/TSX: ZYME) has formally abandoned its ambition to become "Canada's first Big Pharma"
The Weekly Term Sheet (51)
The week of December 15–20, 2025 saw substantial deal flow as companies moved to close transactions before year-end. Total announced deal value exceeded $15 billion across M&A, licensing, royalty acquisitions, and private financings.
Europe's New Biotech Act and Pharma Package: Balancing Innovation and Access
How the EU's December 2025 reforms aim to transform Europe into a biotech powerhouse while keeping medicines affordable—and why success is far from guaranteed
Fund of the week: Baker Brothers Advisors
Baker Brothers Advisors stands as arguably the most successful biotech-focused hedge fund in history, having generated an estimated $8 billion